In the „Development of new therapeutic strategies for treatment of neutrophilic inflammation in chronic transplant dysfunction after lung transplantation“ project, a patient cohort in Hannover and Munich will be set up across locations with a joint anonymized database.
A suggested parameter for a joint anonymized database/patient cohort has been agreed across locations between Hannover and Munich.

(Research team led by Prof. Dr. Jens Gottlieb)

The „Mechanism of the Bronchiolitis obliterans syndrome (BOS)“ project uses the innovative allogenic orthotopic lung transplantation model in the mouse to induce a BOS, above all in a minor antigen-incompatible stem combination. In this model, with the assistance of suitable knockout mice, candidate molecules for relevance in BOS pathogenesis will be studied. In addition, the relevance of macrophage subpopulations and macrophage activation will be studied in chimerism experiments, as well as the significance of bacterial and viral triggers for BOS genesis.

(Research team led by PD Dr. Gregor Warnecke)