Immunological Aspects

The aim of the „Immunophenotyping of clinical lung recipients before and after transplantation“ project is to carry out differentiated immunomonitoring in a large cohort of patients after lung transplantation, taken from the lung transplant programs at the MHH and CPC Munich (cumulatively in 2011 >180, in 2012 >200 lung transplantations). Together with other parameters, particularly the phenotype of regulatory T-cells will be studied over time after transplantation and correlated with the clinical follow-up data.

The „Immunological transplantation tolerance“ project aims to improve already established protocols for the induction of donor-specific transplantation tolerance in the large animal transplantation model for clinical use. The mechanism of immunotolerance in this model will be further studied on the level of T-cell regulation and the knowledge gained in the lung transplantation prepared for clinical use.