The clinical research group „Molecular Pathology of Cystic Fibrosis“ at the MHH has published more than 150 research papers on basic, translational and clinical cystic fibrosis (CF) research over the past 20 years.

Substantial successes of this research have been the discovery of numerous CF-causative mutations in the CFTR genes, the description of the mutated CFTR phenotypes in vitro, ex vivo and in vivo and the identification of the genetic modifiers of the CF disorder within the European Cystic Fibrosis Twin and Sibling Study. The latest studies focus on the genetic and phenotypic adaptation of Pseudomonas aeruginosa from CF lungs.